Konstantin Gus Kousoulas

Professor of Virology and Biotechnology

 

B.S.  Fairleigh Dickinson University

M.S.  Pennsylvania State University

Ph.D.  Pennsylvania State University

The Paula & Milton Shepard Professor in Veterinary Medicine

Postdoctoral Fellow of the American Cancer Society, 1981-1983, California Department of Health     

NIH Postdoctoral Fellow, 1983-1986, University of California San Francisco, and University of Chicago

Research Assistant Professor, 1986-1988, University of California at San Francisco 

Director of Gene Probe and Expression Laboratory

Dr. Kousoulas has a joint appointment in the Department of Pathobiological Sciences in the School of Veterinary Medicine and the Department of Poultry Science in the LSU Agricultural Center.  He is currently the recipient of the Paula & Milton Shepard Professor in Veterinary Medicine.  He is an adjunct faculty member of the Department of Biological Sciences, College of Basic Sciences, and the Pennington Biomedical Research Center.  Dr. Kousoulas teaches virology and biotechnology in the veterinary medical curriculum and in the graduate programs in veterinary medical sciences and other LSU graduate courses which deal with virology and biotechnology. He has served as a major professor for both M.S. and Ph.D. candidates.  He has participated on the United States Department of Agriculture peer review panel in virology, and as an ad-hoc reviewer of the National Institutes of Health. Dr. Kousoulas founded in 1991 the Gene Probes and Expression Systems Laboratory "Gene Lab" in the Department of Pathobiological Sciences which serves Louisiana researchers as a support and resource facility for research in molecular and cellular biology.  He is the founding President of the Louisiana Molecular Biology and Biotechnology Development Alliance (LAMBBDA), a not-for-profit corporation with a mission to enhance molecular biology and biotechnology in Louisiana.  Dr. Kousoulas participates in the Multidisciplinary Program in Infectious Disease.

Research Interests

Dr. Kousoulas's research interests are focused on the molecular biology and pathogenesis of herpesvirus and coronaviruses.  Experimental approaches in his laboratory involve advanced molecular biology, molecular genetics and cell biology to study viral attachment, viral penetration into cells, cellular receptors and virus spread.  Other interests include the application of viral vectors for gene therapy, the development of DNA based methods for the diagnosis of infectious disease pathogens and genetic diseases, and the utilization of computers for biological research and teaching. These studies  are supported by the National Institutes of Health, the United States Department of Agriculture, the Louisiana Educational Quality Support Fund and industrial sources.

Selected Publications

Lin, X.Z., V. N. Chouljenko, K.G. Kousoulas, and J. Storz.  2000. Temperature-sensitive acetylesterase activity of haemagglutinin-esterase specified by respiratory bovine coronaviruses.  J. Med. Virol. 49:1-9.

Storz, J., X. Q. Lin, C.W. Purdy, V.N. Chouljenko, K.G. Kousoulas, F.M. Enright, W.C. Gilmore, R.E. Briggs, and R.W. Loan.  2000.  Coronavirus and Pateurella infections in bovine shipping fever pneumonia and Evans, criteria for casusation.  J. Clin. Microb. 38:3291-3298.

Wang, Q.J., F.J. Jenkins, L.P. Jacobson, Y.X. Meng, P.E. Pellett, L.A. Kingsley, K.G. Kousoulas, A. Baghian, and C.R. Rinaldo Jr.  CD8+ cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodficiency virus type-1 infected and uninfected individuals.  J. Infect Dis. 2000. Sep; 182(3): 928-32.

Chouljenko, V.N., .X.Q. Lin, J. Storz, and K.G. Kousoulas.  2001.   Elucidation of the genomic nucleotide sequence of bovine coronavirus and analysis of cryptic leader-mRNA fusions sites and their role in the genertion of subgenomic mRNA quasispecies.  Adv. Virus Res.  In Press.

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