Education:
B.S. University of Wisconsin-River Falls Ph.D. University of Missouri, School of Medicine
Postdoctoral fellow at Rocky Mountain Laboratories, NIAID, NIH, 1998-2003.
Research Interests
Dr. Petersons primary research interest is studying the role of the
host response in viral pathogenesis. Current research in the laboratory is
focused on the contribution of the innate immune response to
retrovirus-induced neurological disease, with a concentration on the
involvement of proinflammatory cytokines, chemokines and toll-like
receptors. Experimental procedures in the laboratory include real-time PCR,
RNAse Protection Assay and in situ hybridization analysis of gene
expression, the use of retroviral vectors and neural stem cells for in
vivo gene expression, and the use of knockout mice to study the
contribution of specific genes during retroviral neuropathogenesis.
Selected Publications
Corbin, M. E., S. Pourciau, T. W.
Morgan, M. Boudreaux, and K. E. Peterson. 2006. Ligand up-regulation does
not correlate with a role for CCR1 in pathogenesis in a mouse model of
non-lymphocyte mediated neurological disease. J. Neurovirol. 12:1-10
Peterson, K.E., Evans LH, Wehrly, K and B. Chesebro. 2006.
Increased proinflammatory cytokine and chemokine responses and microglial
infection following inoculation with neural stem cells infected with
polytropic murine retroviruses. Virology. In press.
Peterson, K.E. and B. Chesebro. 2006.
Influence of proinflammatory cytokines and chemokines on the
neuropathogenesis of oncornavirus and immunosuppressive lentivirus
infections. Curr. Top. Microbiol Immunol. 303:67-95
Evans, L.H., Lavignon, H., Peterson, K.E., Hasenkrug, K., Robertson, S.,
Malik, F. and K. Virtaneva. 2006.
In Vivo Interactions of Ecotropic and Polytropic Murine 1 Leukemia Viruses
in Mixed Retrovirus Infections. J. Virology. 80:4748-57.
Peterson, K.E., Hughes. S., Dimcheff, D.E., Wehrly, K., and B. Chesebro. (2004). Separate sequences in a murine retroviral envelope protein mediate neuropathogenesis by complementary mechanisms with differing requirements for tumor necrosis factor alpha. J Virol. 78:13104-12.
Messer, R.J., Dittmer, U., Peterson, K.E., and K.J. Hasenkrug (2004). Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection. Proc Natl Acad Sci U S A. 101:12260-5
Peterson, K. E., J.S. Errett, T. Wei, D.E. Dimcheff, R Ransohoff., W.A. Kuziel, L. Evans,, and B. Chesebro. (2004). MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice; role for astrocytes in retroviral neuropathogenesis. J.Virol. 78: 6449-58
Dittmer, U., He, H. Messer, R.J., Schimmer, S., Olbrich, A.R.M., Ohlen, C. Greenberg, P.D., Stromnes, I.M., Iwashiro, M., Sakaguchi, S., Evan, L.H., Peterson K.E., Yang, G. and K.J. Hasenkrug. (2004). Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral infection. Immunity 20:293-303
Peterson, K.E., Stromnes, I., Messer, R., Hasenkrug, K.J. and B. Chesebro. (2002). Novel role of CD8+ T cells and MHC class I genes in the generation of protective CD4+ Th1 responses during retrovirus infection in mice. J. Virol.76(16):7942-8.
Dittmer, U., Race, B., Peterson, K.E., Stromnes, I.M., Messer, R.J., and K.J. Hasenkrug. (2002). Essential Roles for CD8+ T Cells and Gamma Interferon in Protection of Mice against Retrovirus-Induced Immunosuppression. J Virol. 76(1):450-4.
Iwashiro, M., Messer, R.J., Peterson, K.E., Stromnes, I.M., Sugie, T., and K.J. Hasenkrug. (2001). Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection. Proc. Natl. Acad. Sci. U.S.A. 98(16):9226-30.
Peterson, K.E., Roberston, S., Portis, J. and B. Chesebro. (2001). Differences in cytokine and chemokine responses during neurological disease induced by polytropic murine retroviruses map to separate regions of the viral envelope gene. J. Virol. 75(6):2848-56.
Dittmer, U., Peterson, K.E., Messer, R., Stromnes, I.M., Race, B. and K.J. Hasenkrug. (2001). Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Fried retrovirus infection. J Virol. 75(2):654-60.
Iwashiro, M., Peterson, K.E., Messer, R.J., Stromnes, I.M., and K.J. Hasenkrug. (2001). CD4+ T cells and Gamma Interferon in the Long-Term Control of Persistent Friend Retrovirus Infection. J Virol. 75(1):52-60.
Peterson, K.E., Iwashiro, M., Hasenkrug, K.J., and B. Chesebro. (2000). Major histo-compatibility complex class I gene controls the generation of gamma interferon-producing CD4+and CD8+ T cells important for recovery from friend retrovirus-induced leukemia. J. Virol. 74(11):5363-7.
Peterson, K.E. and H. Braley-Mullen. (1999). CD40L is necessary for the priming of effector cells for lymphocytic and granulomatous experimental autoimmune thyroiditis. J. Autoimmun. 12(1):1-12.
Peterson, K.E., Sharp, G.C., Tang, H., and H. Braley-Mullen. (1999). B7.2 has opposing roles during the activation versus effector stages of experimental autoimmune thyroiditis. J. Immunol. 162(3):1859-67.
|
