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Education:
DVM, Kansas State University • MS, Kansas State University • PhD, Oklahoma State University
Diplomate, American College of Veterinary Pathologists
Dr. Paulsen received his DVM in 1977 and MS in 1978 from Kansas State University. He was in private mixed, mostly bovine, veterinary practice until 1986, when he returned to get his PhD degree in Veterinary Pathology from Oklahoma State University in 1989. An Assistant Professor in Veterinary Pathology at LSU from 1989 to 1995, and Associate Professor at Mississippi State University from 1996-2000, he returned to LSU as a Professor in Pathobiological Sciences in August of 2001.
Research Interests
Bovine respiratory disease (shipping fever) has been a continuous research interest of his, especially the pathogenesis and immunity of disease caused by Mannheimia haemolytica. He is currently also involved in research using a murine model of asthma and a murine model of neurovirulence in herpesviruses.
Selected Publications
Penn AL, Rouse RL, Horohov DW, Kearney MT,
Paulsen DB, Lomax L. In utero Exposure to Environmental Tobacco
Smoke Potentiates Adult Responses to Allergen in BALB/c Mice. Environ
Health Perspect (in press).
Polikepahad S, Paulsen DB, Moore RM, Costa LR, Venugopal CS.
Immunohistochemical determination of the expression of endothelin
receptors in bronchial smooth muscle and epithelium of healthy horses and
horses affected by summer pasture-associated obstructive pulmonary
disease. Am J Vet Res. 2006 Feb;67(2):348-57.
Bowles KS,
Horohov DW, Paulsen DB, LeBlanc CJ, Littlefield-Chabaud MA, Ahlert T,
Ahlert K, Pourciau SS, Penn A. Exposure of adult mice to environmental
tobacco smoke fails to enhance the immune response to inhaled antigen.
Inhal Toxicol. 17:43-51. 2005.
Murray BP,
Greiter-Wilke A, Paulsen DB, Hyatt KM, Beltrami CA, Marchetti D.
Selective heparanase localization in malignant melanoma. Int J Oncol.
26:345-352. 2005.
Reeks BY,
Champlin FR, Paulsen DB, Scruggs DW, Lawrence ML.
Effects of sub-minimal inhibitory concentration antibiotic levels on growth
kinetics and outer membrane protein expression in Mannheimia haemolytica
and Haemophilus somnus. Can J Vet Res. 2005
Jan;69(1):1-10.
Faleiros RR,
Stokes AM, Eades SC, Kim DY, Paulsen DB, Moore RM:
Assessment of apoptosis in epidermal lamellar cells in clinically normal
horses and those with laminitis. Am J Vet Res 65 (5) 578-585,
2004.
Chen L,
Paulsen DB, Scruggs DW, Banes MM, Reeks BY, and Lawrence ML.
Alteration of DNA adenine methylase (Dam) activity in Pasteurella
multocida causes increased spontaneous mutation frequency and
attenuation in mice. Microbiol 2003 Aug;149(Pt 8):2283-90.
LeBlanc KA, Stout RW, Kearney MT, Paulsen DB. Comparison of Adhesion Formation Associated with Pro-Tack (US Surgical) Versus a New Mesh Fixation Device, Salute (ONUX Medical). Surg Endoscopy
J. 2003 Jun 17.
Paulsen DB, Buddington KK, Buddington RK. Dimensions and histology of the canine small intestine during postnatal development. Am J Vet Res
2003 May;64(5):618-26.
Yoder-Reeks B, Champlin FR, Paulsen DB, Scruggs D, Lawrence ML. Effects of sub-MIC levels chlortetracycline and AS700 on some virulence factors of Mannheimia haemolytica. Am J Vet Res (submitted).
Paulsen DB, Kern MR, Weigand, CM. Mycobacterial neuritis in a cat. J Am Vet Med Assoc. 216:1589-1591, 2000.
Eddlestone S, Taboada J, Senior D, and Paulsen D. Renal hemangioma in a dog. J Sm Anim Pract, 40:132-135, 1999.
Brennan RE, Corstvet RE, Paulsen DB. Antibody responses to Pasteurella haemolytica 1:A and three of its outer membrane proteins in serum, nasal secretions, and bronchoalveolar lavage fluid from calves. Am J Vet Res, 59:727-732, 1998.
McBride JW, Corstvet RE, Paulsen DB, McClure JR, Enright FM. Characterization of bovine pulmonary and serum antibody responses after parenteral or intrapulmonary vaccination with live Pasteurella haemolytica. Comp Immunol Microbiol Infect Dis. 19:99-115, 1996.
Paulsen DB, Confer AW, Clinkenbeard KD, Mosier DA. Pasteurella haemolytica lipopolysaccharide-induced cytotoxicity in bovine pulmonary artery endothelial monolayers: inhibition by indomethacin. Vet Pathol. 32:173-183, 1995.
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