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James E. Miller
Professor, Parasitology
Laboratory:
Phone:
225-578-9652
Fax:
225-578-9701
jmille1@lsu.edu |
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Education:
B.S. University of New Mexico • D.V.M. University of California, Davis • M.P.V.M. University of California, Davis
• Ph.D. University of California, Davis
Dr. James E.
Miller has been a member of the faculty since 1984; he was appointed
full Professor in 1995 and was Acting Head of the former Department of
Epidemiology and Community Health (1999 2001). He is currently serving
as Interim Associate Dean for Research and Advanced Studies and is the
Everett D. Besch Professor of Veterinary Medicine.
He is author and/or coauthor of over 90 refereed journal articles,
numerous technical/report papers, proceedings papers, and abstracts, and
7 book chapters. He is a research collaborator with numerous national
and international organizations including Utah State University (Logan,
UT); the University of Georgia (Athens, GA); Virginia Tech University
(Blacksburg, VA); Fort Valley State University (Fort Valley, GA); USDA
ARS, Booneville, AR; Disney's Animal Kingdom; San Diego Wild Animal
Park; Busch Gardens Tampa; the International Livestock Research
Institute (Nairobi, Kenya); the Roslin Institute (Edinburgh, Scotland);
the University of Otego (Dunnedin, NZ); the Moredun Research Institute
(Edinburgh, Scotland); the Danish Centre for Experimental Parasitology
(Copenhagen, Denmark); and Departmento de Helmintologia Centro Nacional
de Investigacion Disciplinaria Eenparasitologia Veterinaria (INIFAP),
Municipio de Jiutepec, (Estado de Morelos, México).
He is affiliated with several professional organizations and is
currently participating on 3 USDA National Projects: 1) NRSP-8:
Cattle/Sheep Animal Genome Technical Committee, National Animal Genome
Research Program, National Research Support Program, 2) NCERA-214:
Increased Efficiency of Sheep Production and 3) SCC-81: Sustainable
Small Ruminant Production in the Southeastern U.S.
He is a co founder of the Southern Consortium for Small Ruminant
Parasite Control. The Consortium’s primary purpose is to evaluate and
promote alternative non chemical methods for controlling nematode
parasites. His teaching assignments include several professional and
graduate courses in the School of Veterinary Medicine and undergraduate
courses in the Department of Animal Science.
Research Interests
Dr. Miller is the
principal investigator for several competitive and industry supported
grants dealing with the epidemiology, control, and genetics of ruminant
nematode parasitism. His research program focuses on improving ruminant
production using an integrated approach to controlling parasites. His
area of special expertise is small ruminant gastrointestinal nematode
parasitism, which is the most serious constraint affecting production
world wide. Economic losses are caused by decreased production, costs of
prophylaxis, costs of treatment, and the death of infected animals.
Anthelmintic resistance in nematode populations (specifically affecting
small ruminants) threatens the success of treatment programs. Dr.
Miller's research is directed at developing alternative strategies for
control.
His current research program is
two-fold: 1) To determine why, and/or how, Gulf Coast Native sheep are
relatively more resistant to gastrointestinal nematode infection than
Suffolk sheep, and 2) To evaluate alternative (non chemical) approaches
for protection against nematode infection. In 1), his lab is evaluating
segregation of resistance leading to identification of closely linked
genetic microsatellite markers associated with resistance using an F2
reference family approach. Such genetic markers can then be used for
selection purpose and for fine mapping of the quantitative trait loci (QTL).
They are also characterizing differences in the host immune response
(Th1 vs. Th2) that might account for resistance. In 2), they are
evaluating nematode trapping fungi, condensed tannin containing plants,
copper wire particles, and vaccination protocols in conjunction with
strategic use of anthelmintics for use in integrated control programs.
Selected Publications
Burke, J.M.,
Orlik, S., Miller, J.E., Terrill, T.H., Mosjidis, J.A., 2010. Using
copper oxide wire particles or sericea lespedeza to prevent a peri‑parturient
gastrointestinal nematode infection in sheep and goats. Livestock Sci
132, 13-18.
DeRouen, S.M.,
Miller, J.E., Foil, L.D., 2010. Control of horn flies (Haematobia
irritans) and gastrointestinal nematodes and its relation with growth
performance in stocker cattle. Prof Anim Scientist 26, 109-114.
Soli, F., Terrill,
T.H., Shaik, S.A., Getz, W.R., Miller, J.E., Vanguru, M., Burke, J.M., 2010.
Efficacy of copper oxide wire particles against gastrointestinal nematodes
in sheep and goats. Vet Parasitol 168, 93-96.
Burke, J.M., Soli,
F., Miller, J.E., Terrill, T.H., Wildeus, S., Shaik, S.A., Getz, W.R.,
Vanguru, M., 2010. Administration of copper oxide wire particles in a
capsule or feed for gastrointestinal nematode control in goats. Vet
Parasitol 168, 346-350.
Burke, J.M., Wells,
A., Casey, P., Miller, J.E., 2009. Garlic and papaya lack control over
gastrointestinal nematodes in goats. Vet Parasitol 159, 171-174.
Shakya, K.P.,
Miller, J.E., Horohov, D.W., 2009. A Th2 type of immune response is
associated with increased resistance to Haemonchus contortus in
naturally infected Gulf Coast Native lambs. Vet Parasitol 163,
57-66.
Burke, J.M., Miller,
J.E., Terrill, T.H., 2009. Impact of rotational grazing on gastrointestinal
nematodes in weaned lambs. Vet Parasitol 163, 67-72.
Derouen, S.M.,
Miller, J.E., Foil, L.D., Gentry, G.T., 2009. Control of horn flies (Haematobia
irritans) and gastrointestinal parasites and its relation with cow-calf
performance. Vet Parasitol 162, 320-326.
Terrill, T.H.,
Dykes, G.S., Shail, S.A., Miller, J.E., Kouakou, B., Kannan, G., Burke, J.M.,
Mosjidis, J.A., 2009. Efficacy of sericea lespedeza hay as a natural
dewormer in goats: Dose titration study. Vet Parasitol 163, 52-56.
Chaudary, F.R.,
Qayyum, M., Khan, M.F.U., Ahmad, T., Khanum, A., Shakir, M.R., Hussain, D.,
Miller, J.E., 2009. The peri-parturient rise in feacal nematode egg counts
with reference to Haemonchus contortus in Bulkhi ewes in northern
Punjab, Pakistan. Pakistan J Zool 41, 437-443.
Whitley, N.C.,
Miller, J.E., Burke, J.M., Cazac, D., Jackson-O'Brien, D., Dykes, L., Muir,
J.P., 2009. Effect of high tannin grain sorghum on gastrointestinal parasite
fecal egg counts in goats. Small Rumin Res 87, 105-107.
Worku, M., Franco,
R.A., Miller, J.E., 2009. Evaluation of the activity of plant extracts in
Boer goats. Amer J Anim Vet Sci 4, 72-79.
Burke, J.M., Miller, J.E., 2008. Use of FAMACHA system to evaluate
gastrointestinal nematode resistance in offspring of stud rams.
Vet Parasitol 153, 185-192.
Hunt, P.W., McEwan, J.C., Miller, J.E., 2008. Future perspectives for the
implementation of genetic markers for parasite resistance in sheep.
Trop Biomed 25, 18-33.
Burke, J.M., Terrill, T.H., Kallu, R.R., Miller, J.E., Mosjidis, J. 2007. Use of copper
oxide wire particles to control gastrointestinal nematodes in goats.
J Anim Sci 85, 2753-2761.
Burke, J.M., Kaplan, R.M., Miller, J.E., Terrill, T.H., Getz, W.R., Mobini,
S., Valencia, E., Williams, M.J., Williamson, L.H., Vatta, A.F. 2007.
Accuracy of the FAMACHA system for on-farm use by sheep and goat producers
in the southeastern United States. Vet
Parasitol 147, 89-95.
Burke, J.M., Morrical, D., Miller, J.E., 2007. Control of gastrointestinal
nematodes with copper oxide wire particles in a flock of Polypay ewes and
offspring in Iowa. Vet Parasitol
146, 372-375.
Terrill, T.H., Mosjidis, J.A., Moore, D.A., Shaik, S.A., Miller, J.E.,
Burke, J.M., Muir, J.P., Wolfe, R., 2007. Effect of pelleting on efficacy of
sericea lespedeza hay as a natural dewormer in goats.
Vet Parasitol 146, 117-122.
Lange, K.C.,
Olcott, D.D., Miller, J.E., Mosjidis, J.A., Terrill, T.H., Burke, J.M.,
Kearney, M.T., 2006. Effect of sericea lespedeza, fed as hay, on natural and
experimental Haemonchus contortus infections in lambs. Vet
Parasitol 141, 273-278.
Miller, J.E., Bishop, S.C., Cockett, N.E., McGraw, R.A., 2006. Segregation
of natural and experimental gastrointestinal nematode infection in F2
progeny from susceptible Suffolk and resistant Gulf Coast Native sheep and
its usefulness in assessing genetic variation.
Vet Parasitol 140, 83-89.
Jackson, F., Miller, J.E., 2006. Alternative approaches to control –
Quo vadis. Vet Parasitol
139, 371-384.
Burke, J.M., Miller, J.E., 2006. Evaluation of multiple low dose copper
oxide wire particle boluses for control of
Haemonchus contortus in lambs.
Vet Parasitol 139, 145-149.
Peña, M.T., Miller, J.E., Horohov, D.W., 2006. Effect of CD4+ T
lymphocytes depletion on resistance of Gulf Coast Native lambs to
Haemonchus contortus infection.
Vet Parasitol 138, 240-246.
Miller, J.E., Horohov, D.W., 2006. Immunological aspects of nematode parasite control. J Anim Sci 84 Suppl E124-32.
Flemming, S.A., Craig. T., Kaplan, R., Miller, J.E., Navarre, C, Riggs, M., 2006. Anthelmintic resistance of gastrointestinal parasites in small ruminants. J Vet Intern Med 20, 435-441.
Burke, J.M., Miller, J.E., Brauer, D.K., 2005. The effectiveness of copper wire particles as an anthelmintic in pregnant ewes and safety to offspring. Vet. Parasitol. 131, 291-297.
Burke, J.M., Miller, J.E., Larsen, M., Terrill, T.H., 2005. Interaction between copper oxide wire particles and Duddingtonia flagrans in lambs. Vet Parasitol 134, 141-146.
Terrill, T.H., Larsen, M., Samples, O., Husted, S., Miller, J.E., Gelaye, S., 2004. Capability of the nematode-trapping fungus Duddingtonia flagrans to reduce infective larvae of Haemonchus contortus in goat feces in the southeastern United States: Dose titration and dose timing interval studies. Vet Parasitol 120:285-296.
Peña, M.T., Miller, J.E., Horohov, D.W., 2004. Effect of dexamethasone treatment on the immune response of Gulf Coast Native lambs to Haemonchus contortus infection. Vet Parasitol 119: 223-235.
Fontenot, M.E., Miller, J.E., Peña M.T., Larsen, M., Gillespie, A., 2004. Efficiency of feeding Duddingtonia flagrans chlamydospores to grazing ewes on reducing availability of parasitic nematode larvae on pasture. Vet Parasitol 118, 203-213.
Burke J.M., Miller, J.E., 2002. Relative resistance of Dorper crossbred ewes to gastrointestinal nematode infection compared with St. Croix and Katahdin ewes in the southeastern United States. Vet Parasitol 109: 265-275.
Peña, M.T., Miller, J.E., Fontenot, M.E., Gillespie, A., Larsen, M., 2002. Evaluation of Duddingtonia flagrans in reducing infective larvae of Haemonchus contortus in feces of sheep. Vet Parasitol 103: 259-265.
Terrill, T.H., Kaplan, R.M., Larsen, M., Samples, O.M., Miller, J.E., and Gelaye, S., 2001. Anthelmintic Resistance on Goat Farms in Georgia—Efficacy of Anthelmintics Against Gastrointestinal Nematodes in Two Selected Goat Herds. Vet Parasitol 97: 261-268.
Li, Y., Miller, J.E., and Franke, D.E., 2001. Epidemiological observation and heterosis of gastrointestinal nematode infection in Suffolk, Gulf Coast Native and crossbred lambs. Vet Parasitol 98: 273-283.
Peña, M.T., Miller, J.E., Wyatt, W., and Kearney, M.T., 2000. Differences in susceptibility to gastrointestinal nematode infection between Angus and Brangus cattle in south Louisiana. Vet Parasitol 89: 51-61.
Kabagambe, E.K., Barras, S.R., Li., Y., Peña, M.T., Smith, W.D., and Miller, J.E., 2000. Attempts to control haemonchosis in grazing ewes by vaccination with gut membrane proteins of the parasite. Vet Parasitol 92: 15-23.
Miller, J.E., Bahirathan, M., Lemarie, S.L.,et al., 1998. Epidemiology of gastrointestinal nematode parasitism in Suffolk and Gulf Coast Native sheep with special emphasis on relative susceptibility to Haemonchus contortus infection. Vet Parasitol 74: 55-74.
Bahirathan, M., Miller, J.E., Barras, S.R., et al., 1996. Susceptibility of Suffolk and Gulf Coast Native suckling lambs to naturally acquired strongylate nematode infections. Vet Parasitol 65: 259-268.
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