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Leslie D. McLaughlin
Assistant Professor
Laboratory:
Phone: 225-578-9717
Fax:
225-578-9720
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Education:
B.A. Duke University • DVM Louisiana State
University • PhD Louisiana State University
Research Interests:
Dr McLaughlin’s initial
research interests have focused on cellular stress, heat shock proteins, and
the unfolded protein response. In studies using inbred mice, she was able to
show wide variations in levels of voluntary wheel running, suggesting
possible epigenetic effects on this behavior. In gene array studies
comparing high runners with low runners or sedentary mice, however, she
showed that there was a downregulation of the endoplasmic reticulum
“unfolded protein” response, suggesting that voluntary physical activity
reduces stress on the brain, in contrast to its effects on muscle, for
example. This reduction in the unfolded protein response suggests that high
running mice produce fewer defective proteins. This effect may be integral
to the recognized role of physical activity in preventing or delaying the
onset of neurodegenerative diseases. In addition, Dr McLaughlin’s research
interests also include the molecular pathogenesis of neoplasia, more
specifically, manipulation of DNA damage and repair mechanisms and how it
may affect development of certain types of tumors in inbred and genetically
engineered mouse strains.
Selected Publications:
Jones A, Kirchgessner M,
Mitchell MA,
McLaughlin L, Guzman D. What's Your Diagnosis? Conjunctival
lymphosarcoma. J Ex Pet Med, (in press).
Nevarez J, Guzman D,
Tully TN, McLaughlin, LD, Diagnostic Challenge - Mammary
Fibroadenoma in a rat. Journal of Exotic Animal Medicine 15(4):2006.
Tully TN, Williams J,
McLaughlin LD, Snider TG, What is Your Diagnosis? Journal of Avian
Medicine and Surgery. 14(4):2000.
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