.
Education:
B.S. Colorado State University M.S. Sul Ross State University Ph.D. Oklahoma State University
NIH-supported postdoctoral fellowship at the University of Maryland, Baltimore, School of Medicine
Research Interests
Dr. Macalusos research focuses on tick- and
flea-borne rickettsial diseases and how the interactions between
arthropods and rickettsiae facilitate pathogen transmission.
Experimental procedures in his laboratory include assays to determine
the transcriptional and translational regulation of arthropod host
molecules during rickettsial infection. Specifically, the roles that
individual molecules play in cell attachment, entry, and cell-to-cell
spread are investigated. Additional interests include the ecology of
rickettsial diseases including analysis of vector competence.
Selected Publications
Reif KE, Macaluso KR.
Ecology of Rickettsia felis: a review.
J Med Entomol.
2009 Jul;46(4):723-36. PMID: 19645274 [PubMed - in process]
Reif KE, Stout RW, Henry GC, Foil LD, Macaluso KR.
Prevalence and infection load dynamics of Rickettsia felis in
actively feeding cat fleas. PLoS ONE. 2008 Jul 30;3(7):e2805.
Zanettii AS, Pornwiroon W, Kearney MT, Macaluso KR.
Characterization of rickettsial infection in Amblyomma americanum
(Acari: Ixodidae) by quantitative real-time polymerase chain reaction.
J Med Entomol. 2008 Mar;45
(2):267-75.
Macaluso KR, Pornwiroon W, Popov VL, Foil LD.
Identification of Rickettsia felis in the salivary glands of cat
fleas. Vector Borne Zoonotic Dis. 2008 Jun; 8(3):391-6.
Sunyakumthorn P, A Bourchookarn, W Pornwiroon, C David, SA
Barker, and KR Macaluso.
Characterization and growth of polymorphic Rickettsia felis in a
tick cell line. Appl Environ Microbiol. 2008 May;74(10):3151-8.
Epub 2008 Mar 21.
KR Macaluso, Pornwiroon W, VL Popov, Foil
LD.
Identification of Rickettsia felis in the salivary glands of cat
fleas. Vector Borne Zoonotic Dis 2008; In Press.
AS Zanetti, Pornwiroon W, Kearney MT, KR Macaluso.
Characterization of rickettsial infection in Amblyomma americanum
(Acari:Ixodidae) by quantitative real-time PCR. J Med Entomol
2008; 45:267-275.
Pornwiroon W, Husseneder C, Kearney MT, Foil LD,
KR Macaluso. Comparative microbiota of Rickettsia felis-uninfected
and -infected colonized cat fleas, Ctenocephalides felis. ISME
J 2007: 1:394-402.
Macaluso KR, A Mulenga,
JA Simser, and AF Azad.
Characterization of Dermacentor variabilis molecules associated with
rickettsial infection. Ann NY Acad Sci. 2006; 1078: 384-388.
Pornwiroon W, SS Pourciau, LD Foil, and KR Macaluso.
Rickettsia felis from cat fleas: Isolation and culture in a
tick-derived cell line. App Environ Microbiol. 2006;
72:5589-5595.
Henry K, J Jiang, PJ Rozmajzl, AF Azad, KR Macaluso, AL Richards.
Development of quantitative real-time PCR assays to detect Rickettsia
typhi and Rickettsia felis, the causative agents of murine typhus
and flea-borne spotted fever. Molec & Cell Probes. 2007:21:17-23.
Macaluso KR, A Mulenga, JA Simser, and AF Azad. Differential expression of genes in uninfected and Rickettsia-infected Dermacentor variabilis as assessed by differential display PCR. Infect Immun. 2003; 71:6165-6170.
Rutherford JS, KR Macaluso*, N Smith, SR Zaki, CD Paddock, JM Davis, N Peterson, AF Azad, and R Rosenberg. A case of fatal spotted fever rickettsiosis in Kenya. Emerg Infect Dis 2004; 10:910-913.
Macaluso KR, J Davis, U Alma, A Korman, J Rutherford, R Rosenberg, and AF Azad. Spotted fever group rickettsiae in ticks from the Masai Mara region of Kenya. Am J Trop Med Hyg 2003; 68:551-553.
Macaluso KR, A Mulenga, JA Simser, and AF Azad. Interactions between rickettsiae and Dermacentor variabilis ticks: analysis of gene expression. Ann NY Acad Sci. 2003; 990:568-572.
Macaluso KR, DE Sonenshine, SM Ceraul, and AF Azad. Infection and transovarial transmission of rickettsiae in Dermacentor variabilis acquired by artificial feeding. Vector Borne Zoonotic Dis 2001; 1:45-53.
Macaluso KR, DE Sonenshine, SM Ceraul, and AF Azad. Rickettsial infection in Dermacentor variabilis (Acari: Ixodidae) inhibits transovarial transmission of a second Rickettsia. J Med Entomol 2002; 39:809-813.
Macaluso KR and SK Wikel. Dermacentor andersoni: effects of repeated infestations on lymphocyte proliferation, cytokine production, and adhesion-molecule expression by BALB/c mice. Ann Trop Med Parasitol 2001; 95:413-427.
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