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Thomas R. Klei
Boyd Professor, Parasitology and
Veterinary Science
Associate Dean for Research and Academic Affairs
Laboratory:
Phone: 225-578-9900
Fax: 225-578-9916
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Education:
B.S. Northern Michigan University • Ph.D.
Wayne State University • NIH Postdoctoral Fellow, 1971-73, University of
Georgia
Dr. Klei
has a joint appointment in the Department of Pathobiological Sciences the
School of Veterinary Medicine and the Department of Veterinary Science in
the LSU Agricultural Center. He also serves as Associate Dean for Research
and Advanced Studies. Dr. Klei lectures and teaches laboratory courses on
parasitology and immunology in the veterinary medical curriculum and in
the graduate program in veterinary medical sciences. He has served as
major and minor professor for both MS and Ph.D. candidates. He is a past
president of the American Association of Veterinary Parasitologists and
serves on the editorial boards of Parasite Immunity and the
Compendium for Continuing Education for the Practicing Veterinarian.
He is a consultant to the pharmaceutical industry on the development of
veterinary anthelmintics, and vaccines and he has served on grant peer
review panels for the United States Department of Agriculture, National
Institutes of Health, and the World Health Organization.
Research Interests
His
research activities are related to the host immune response to parasitic
nematode infection as it develops into either protection from infection or
pathology. Specific involvements include the study of immunopathogenic and
regulatory mechanisms involved in human and animal filariasis. These
studies, are primarily of laboratory animal models for human lymphatic
filariasis. Dr. Klei also maintains an interest on the basic and applied
aspects of equine parasite control. He has several projects on equine
parasites which include characterization of the immune response to
nematode infections, studies on basic biologic and chemotherapeutic
control measures useful against internal parasites of horses, and the
epidemiology of equine nematode infections in Louisiana.
Selected Publications
Chirgwin SR, Coleman SU, Klei TR. 2007.
Brugia
pahangi: In vivo tissue migration of early L3 alters gene expression.
Exp Parasitol (In Press).
Traversa D, Iorio R, Klei TR, Kharchenko VA, Gawor J, Otranto D, and
Sparagano OAE, 2007. Simultaneous species-specific identification of
equine strongyles (Nematoda, Strongylida) by Reverse Line Blot
hybridization: A new method. J Clin Micro. 9: 2937-2942.
Traversa D, Klei TR, Dorio R, Paoletti R, Lia RP, Otranto D, Sparagano OAE,
Giangaspero A. 2007 Occurrence of anthelmintic resistant equine
cyathostome populations in central and southern Italy. Prev Vet Med 82:
314-320.
Chirgwin SR, Coleman SU, Porthouse KH, Klei TR. 2006. Tissue migrating
capability of larval and adult Brugia pahangi. J. Parasitol. 92(1):
46-51.
Porthouse KH, Chirgwin SR, Coleman SU, Taylor HW, Klei TR. 2006.
Inflammatory responses to migrating Brugia pahangi third-stage
larvae. Infect Immun. 74(4):2366-72.
Rao RU, Klei TR. 2006. Cytokine profiles of filarial granulomas in jirds
infected with Brugia pahangi. Fil. J. 16; 5(1):3-10
Chirgwin SR, Rao UR,Coleman SU, Nowling JM, Klei TR. 2005. Profiling the
cellular immune response to multiple Brugia pahangi
infections in a
susceptible host. J Parasitol.91(4):822-829.
Chirgwin SR, Rao UR, Mai Z, Coleman SU, Nowling JM, Klei TR. 2005.
Kinetics of T cell cytokine gene expression in gerbils after a primary
subcutaneous Brugia pahangi
infection. J Parasitol. 91(2):264-8.
Kaplan, RM, Klei, TR, Lyons, ET,Lester, G, Courtney, CH, French, DD,
Tolliver,SC, Vidyashankar, AN, and Zhao,Y 2004 Prevalence of Anthelmintic
Resistance Cyathostomes on Horse Farms. J Am Vet Med Assoc (Accepted)
Dowdall SM, Proudman CJ, Klei TR, Mair T, Matthews JB. 2004.
Characterisation of IgG(T) serum antibody responses to two larval antigen
complexes in horses naturally- or experimentally-infected with
cyathostomins. Int J Parasitol. 34: 101-108.
Coles GC, Eysker M, Hodgkinson J, Matthews JB, Kaplan RM, Klei TR,
Sangster NC 2003. Anthelmintic resistance and use of anthelmintics in
horses. Vet Rec 153: 636.
Chirgwin SR, Coleman SU, Porthouse KH, Nowling JM, Punkosdy GA, Klei TR.
2003. Removal of Wolbachia from
Brugia pahangi is closely
linked to worm death and fecundity but does not result in altered
lymphatic lesion formation in Mongolian gerbils (Meriones unguiculatus).
Infect and Immun. 2003 71:6986-94.
Hubert JD, Seahorn TL, Klei TR, Hosgood G, Moore RM 2003. Temporal effects
of freezing on plasma nitric oxide concentrations in ponies. Can J Vet Res
67:72-74.
Chapman, M.R., Kearney, M.T.,and Klei, T. R. 2003. Equine cyathostome
populations: Accuracy of species composition estimations. Vet Parasitol
116: 15-21.
Dowdall, S.M.J., Proudman, C.J., Love, S., Klei, T.R., and Mathews, J. B.
2003. Purification and analyses of the specificity of two putative
diagnostic antigens for larval cyathostomin infections in horses. Res. Vet
.Sci. 75:223-229.
Chirgwin, S.R., Nowling, J.M., Coleman, S.U., and Klei, T.R. 2003.
Brugia pahangi and
Wolbachia: The Kinetics of Bacteria
Elimination, Worm Viability and Host Responses Following Tetracycline
Treatment. Exp Parasitol. 103: 16-26.
Chirgwin,S. R., Nowling, J.M., Coleman, S.U., and Klei, T.R. 2003 Effect
of immunostimulatory oligodeoxynucliotides on host responses and the
establishment of Brugia phangi in mongolian gerbils (Meriones
unguicualtus) J Parasitol 89: 483-489.
Chapman, M.R., French, D.D., and Klei, T.R. 2003. Prevalence of strongyle
nematodes in naturally infected ponies of different ages and during
different seasons of the year in Louisiana. J Parasitol 89: 309-314.
Hagius, S.D., Edmonds, M.D., and Klei, T.R.2002. Infection outcome and
cytokine gene expression in Brugia pahangi infected gerbils (Meriones
unguiculatus) sensitized with Brucella abortus. Infection and Immunity
11: 5938-5945.
Chapman, M.R. French, D.D., Taylor, H.W., and Klei, T.R. 2002. One season
of pasture exposure fails to induce a protective resistance to
cyathostomes but increases numbers of hypobiotic third stage larvae. J
Parasitol 88: 687-683.
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