DVM University of Peradeniya, Sri Lanka (1992) • PhD
University of Minnesota (2001) •
Postdoctoral Fellow: Yale University (2001–2003), National Jewish Medical
and Research Center (2003–2004)
Instructor, Division of Respiratory Infections, Department of Medicine,
National Jewish Medical and Research Center; Section of Pulmonary and
Critical Care Medicine, Department of Medicine, University of Colorado
Health Sciences Center
Assistant Professor, Division of Respiratory Infections, Department of
Medicine, National Jewish Medical and Research Center; Section of Pulmonary
and Critical Care Medicine, Department of Medicine, University of Colorado
Health Sciences Center
Associate Professor, Department of Pathobiological Sciences, LSU School
of Veterinary Medicine; Section of Pulmonary and Critical Care Medicine,
Department of Medicine, LSU School of Medicine, New Orleans
Associate Editor, Journal of Immunology
Academic Editor, PLoS ONE
Editorial Boards, Clinical and Vaccine Immunology and Infection
Pulmonary Inflammation and Host Defense
The primary focus of my laboratory is to understand the role of
receptor-mediated signaling upon binding of bacteria and/or their products
in the pathogenesis of inflammatory diseases in the lung. In particular,
we are interested in determining the role of Toll-like receptors (TLRs)
and their adaptors in the development of innate immune response in the
lung in a murine model. We use LPS-derived from bacteria to induce acute
lung injury and use Klebsiella pneumoniae, Streptococcus
pneumoniae, Escherichia coli, Pseudomonas aeruginosa,
and Legionella pneumophila to induce pneumonia. Another focus of my
laboratory is to delineate the role of a neutrophil chemokine CXCL5 in
lung inflammation and host defense. Appropriate gene-deficient mice
and human and murine primary cells are being used. The goal of this research is to resolve the mechanisms by
which these bacteria and/or their products cause inflammation in the lung,
and ultimately to design novel treatment and prevention strategies to
attenuate excessive inflammation.
Flight Attendant Medical Research Institute
NIH COBRE Program
NIH R01 Program
NIH American Recovery and Reinvestment Act (ARRA) Program Supplement (to
(For a comprehensive list of
Dr. Jeyaseelan's recent publications,
please refer to PubMed, a service
provided by the National Library of Medicine.)
Cai S, Batra S, Lira S, Kolls JK, Jeyaseelan S*. 2010.
CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via
CXCL2, CXCL5, NF-ĸB,
and MAPKs. Journal of Immunology.185: 6214-25
Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S,
Poncz M, Lee JS and Worthen GS. 2010. CXCL5 Regulates Chemokine
Scavenging and Pulmonary Host Defense to Bacterial Infection. Immunity.
Balamayooran T, Balamayoorag G and Jeyaseelan S*.
2010. Toll-like receptors and NOD-like receptors in pulmonary antibacterial
immunity. Innate Immunity. I16.201-10
Balamayooran G, Batra S, Fessler MB, Happel KI and Jeyaseelan S*.
2009. Mechanisms of Neutrophil Accumulation in the Lungs Against Bacteria.
American Journal of Respiratory Cell and Molecular Biology.
Cai S, Batra S, Shen
L, Wakamatsu N, Jeyaseelan S*. 2009. Both TRIF- and MyD88-dependent
signaling contribute to host defense against pulmonary Klebsiella
infection. Journal of Immunology.183: 6629-33
GM, Zhao B, Jeyaseelan S, Feng JM. 2009. Age-associated parallel
increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in
SJL/J mice. Cellular Immunology. 258: 188-96.
Craig, A, Mai J, Cai S and Jeyaseelan S*. 2009. Neutrophil
Recruitment to the Lungs During Bacterial Pneumonia. Infection and
Immunity. 77: 568-75 (*Corresponding author)
Cai S, Zemans RL, Young SK, Worthen GS and Jeyaseelan S*. 2009. MD-2
Dependent and -Independent Neutrophil Accumulation During E. coli Pneumonia.
American Journal of Respiratory Cell and Molecular Biology. 40: 701-9
Walker JE, Odden AR, Jeyaseelan S, Zhang, P, Bagby GJ, Nelson S and
Happel KI. 2009. Ethanol exposure impairs LPS-Induced Pulmonary LIX
Expression: Alveolar Epithelial Cell Dysfunction as a Consequence of Acute
Intoxication. Alcoholism: Clinical and Experimental Research. 33:
Smoak K, Madenspacher J,
Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB (2008).
Effects of liver x receptor agonist treatment on pulmonary inflammation and
host defense. J Immunol. 180:3305-12.
Young SK, Fessler MB, Liu Y, Malcolm KC, Yamamoto M, Akira S, and Worthen
GS. 2007. TRIF-Mediated Signaling Contributes to Innate Immune Responses
in the Lung During Escherichia coli Pneumonia. Journal of
Immunology - 178:3153-60. (*Corresponding author)
Martin RJ, Rino JG, Jeyaseelan S, Breed R, and Chu HW. 2007. A
Deficient TLR2 Signaling Promotes Airway Mucin Production in Mycoplasma pneumoniae-infected allergic mice. American
Journal of Physiology - Lung Cellular and Molecular Physiology –
Young SK, Yamamoto, Arndt PG, M, Akira S, Kolls JK, and Worthen GS. 2006. TIRAP Is a Critical Mediator of Pulmonary Defense against
Klebsiella pneumonia but Not Pseudomonas aeruginosa. Journal
of Immunology. 177: 538-547 (*Corresponding author)
Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, and Worthen GS. 2005.
TIRAP Is critical for early immune responses in the Lung against E. coli
LPS and viable E. coli. Journal of Immunology. 175:7484-95
Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ and Worthen GS. 2005.
Induction of CXCL5 During Inflammation in the Rodent Lung Involves
Activation of Alveolar Epithelium. American Journal of Respiratory Cell
and Molecular Biology. 32: 531-9 (*Corresponding author)
HW, Jeyaseelan S, Rhino JG, Voelkar DR, Wexler RB, Campbell K,
Harbeck R and Martin RJ. 2005. Toll-like receptor 2 Signaling is critical
for Mycoplasma pneumoniae-induced Airway Mucin
Expression. Journal of Immunology. 174: 5713-9.
Chu HW, Young SK, Freeman MW and Worthen GS. 2005. Distinct Roles of Pattern
Recognition Receptors CD14 and Toll-like Receptor 4 in Acute Lung Injury.
Infection and Immunity. 73: 1754-63. (*Corresponding author)
Fessler MB, Young SK, Jeyaseelan S, Arndt PG, Lieber JG, Nick JA and
Worthen GS. 2005.A Novel Role for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Pulmonary Inflammation and Host Defense. American Journal of
Respiratory and Critical Care Medicine. 171: 606-15.
Chu HW, Young SK and Worthen GS. 2004. Transcriptional Profiling of
Lipopolysaccharide-Induced Murine Acute Lung Injury. Infection and
Immunity. 72: 7247-55 (*Corresponding author)