Faculty

Samithamby Jeyaseelan (Jey)
Associate
Professor

Lung Biology Laboratory

Phone: 225-578-9524 (office)
225-578-9694 (lab)

Fax:
225-578-9701
jey@lsu.edu

Education
DVM University of Peradeniya, Sri Lanka (1992) • PhD University of Minnesota (2001) •
Postdoctoral Fellow: Yale University (2001–2003), National Jewish Medical and Research Center (2003–2004)

Positions

2004-2006
Instructor, Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center

2006-2007
Assistant Professor, Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center

2007-2010
Associate Professor, Department of Pathobiological Sciences, LSU School of Veterinary Medicine; Section of Pulmonary and Critical Care Medicine, Department of Medicine, LSU School of Medicine, New Orleans

 

Professional Service
Associate Editor, Journal of Immunology
Academic Editor, PLoS ONE
Editorial Boards, Clinical and Vaccine Immunology and Infection and Immunity

 

Research Interests
Pulmonary Inflammation and Host Defense
The primary focus of my laboratory is to understand the role of receptor-mediated signaling upon binding of bacteria and/or their products in the pathogenesis of inflammatory diseases in the lung. In particular, we are interested in determining the role of Toll-like receptors (TLRs) and their adaptors in the development of innate immune response in the lung in a murine model. We use LPS-derived from bacteria to induce acute lung injury and use Klebsiella pneumoniae, Streptococcus pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Legionella pneumophila to induce pneumonia. Another focus of my laboratory is to delineate the role of a neutrophil chemokine CXCL5 in lung inflammation and host defense. Appropriate gene-deficient mice and human and murine primary cells are being used. The goal of this research is to resolve the mechanisms by which these bacteria and/or their products cause inflammation in the lung, and ultimately to design novel treatment and prevention strategies to attenuate excessive inflammation.

Current Funding
American Lung Association
Flight Attendant Medical Research Institute
NIH COBRE Program
NIH R01 Program
NIH American Recovery and Reinvestment Act (ARRA) Program Supplement (to R01)

Selected Publications
(For a comprehensive list of Dr. Jeyaseelan's recent publications, please refer to PubMed, a service provided by the National Library of Medicine.)

Cai S, Batra S, Lira S, Kolls JK, Jeyaseelan S*. 2010. CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF-ĸB, and MAPKs. Journal of Immunology.185: 6214-25

Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS and Worthen GS. 2010. CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection. Immunity. 33: 106-17

Balamayooran T, Balamayoorag G and Jeyaseelan S*. 2010. Toll-like receptors and NOD-like receptors in pulmonary antibacterial immunity. Innate Immunity. I16.201-10

Balamayooran G, Batra S, Fessler MB, Happel KI and Jeyaseelan S*. 2009. Mechanisms of Neutrophil Accumulation in the Lungs Against Bacteria. American Journal of Respiratory Cell and Molecular Biology. 2010. 43: 5-16

Cai S, Batra S, Shen L, Wakamatsu N, Jeyaseelan S*. 2009. Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. Journal of Immunology.183: 6629-33

Han GM, Zhao B, Jeyaseelan S, Feng JM. 2009. Age-associated parallel increase of Foxp3(+)CD4(+) regulatory and CD44(+)CD4(+) memory T cells in SJL/J mice. Cellular Immunology. 258: 188-96. 

Craig, A, Mai J, Cai S and Jeyaseelan S*. 2009. Neutrophil Recruitment to the Lungs During Bacterial Pneumonia. Infection and Immunity. 77: 568-75 (*Corresponding author)

Cai S, Zemans RL, Young SK, Worthen GS and Jeyaseelan S*. 2009. MD-2 Dependent and -Independent Neutrophil Accumulation During E. coli Pneumonia. American Journal of Respiratory Cell and Molecular Biology. 40: 701-9 (*Corresponding Author)

Walker JE, Odden AR, Jeyaseelan S, Zhang, P, Bagby GJ, Nelson S and Happel KI. 2009. Ethanol exposure impairs LPS-Induced Pulmonary LIX Expression: Alveolar Epithelial Cell Dysfunction as a Consequence of Acute Intoxication. Alcoholism: Clinical and Experimental Research. 33: 357-65.

 

Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB (2008). Effects of liver x receptor agonist treatment on pulmonary inflammation and host defense. J Immunol. 180:3305-12.

Jeyaseelan S*, Young SK, Fessler MB, Liu Y, Malcolm KC, Yamamoto M, Akira S, and Worthen GS. 2007. TRIF-Mediated Signaling Contributes to Innate Immune Responses in the Lung During Escherichia coli Pneumonia. Journal of Immunology - 178:3153-60. (*Corresponding author)

Wu Q, Martin RJ, Rino JG, Jeyaseelan S, Breed R, and Chu HW. 2007. A Deficient TLR2 Signaling Promotes Airway Mucin Production in Mycoplasma pneumoniae-infected allergic mice. American Journal of Physiology - Lung Cellular and Molecular Physiology – 292: L1064-72

Jeyaseelan S*, Young SK, Yamamoto, Arndt PG, M, Akira S, Kolls JK, and Worthen GS. 2006. TIRAP Is a Critical Mediator of Pulmonary Defense against Klebsiella pneumonia but Not Pseudomonas aeruginosa. Journal of Immunology. 177: 538-547 (*Corresponding author)

Jeyaseelan S*, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, and Worthen GS. 2005. TIRAP Is critical for early immune responses in the Lung against E. coli LPS and viable E. coli. Journal of Immunology. 175:7484-95 (*Corresponding author)

Jeyaseelan S*, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ and Worthen GS. 2005. Induction of CXCL5 During Inflammation in the Rodent Lung Involves Activation of Alveolar Epithelium. American Journal of Respiratory Cell and Molecular Biology. 32: 531-9 (*Corresponding author)

Chu HW, Jeyaseelan S, Rhino JG, Voelkar DR, Wexler RB, Campbell K, Harbeck R and Martin RJ. 2005. Toll-like receptor 2 Signaling is critical for Mycoplasma pneumoniae-induced Airway Mucin Expression. Journal of Immunology. 174: 5713-9.

Jeyaseelan S*, Chu HW, Young SK, Freeman MW and Worthen GS. 2005. Distinct Roles of Pattern Recognition Receptors CD14 and Toll-like Receptor 4 in Acute Lung Injury. Infection and Immunity. 73: 1754-63. (*Corresponding author)

Fessler MB, Young SK, Jeyaseelan S,  Arndt PG, Lieber JG, Nick JA and Worthen GS. 2005.A Novel Role for 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Pulmonary Inflammation and Host Defense. American Journal of Respiratory and Critical Care Medicine. 171: 606-15.

Jeyaseelan S*, Chu HW, Young SK and Worthen GS. 2004. Transcriptional Profiling of Lipopolysaccharide-Induced Murine Acute Lung Injury. Infection and Immunity. 72: 7247-55 (*Corresponding author)

 




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