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 SCHOOL OF VETERINARY MEDICINE

Theriogenology VMED 5361

SURGERY OF THE FEMALE REPRODUCTIVE SYSTEM

Fall 2003

Dr. J. Davidson

 

Surgical Conditions of the Ovaries. 2

Congenital Anomalies 2

Ovarian agenesis 2

Ovarian hypoplasia.......... 2

Supernumerary ovaries 2

True hermaphroditism 2

Pseudohermaphroditism..... 2

Ovarian Cysts...... 2

Follicular cysts... 2

Luteal cysts... 3

Parovarian cysts 3

Ovarian Neoplasia 3

Surgical Conditions of the Uterus... 4

Pyometra 4

Hydrometra/Mucometra 5

Subinvolution of Placental Sites....... 5

Metritis.... 5

Uterine Torsion... 5

Uterine Prolapse. 5

Uterine Rupture... 6

Uterine Neoplasia 6

Common Surgeries of the Uterus... 6

Ovariohysterectomy (OHE or OVH)....... 6

Indications.......... 6

Preoperative evaluation............ 6

Complications..... 7

Cesarean Section... 7

Indications.......... 7

Preoperative care 7

Anesthetic protocols............ 8

Surgical technique............ 8

Surgical Conditions of the Vagina, Vestibule, and Vulva........... 9

Congenital Abnormalities.............. 9

Segmental Vaginal Aplasia or Hypoplasia.......... 9

Persistent Hymen. 9

Rectovaginal/Rectovestibular Fistula 10

Acquired Abnormalities............ 10

Vaginal Edema (vaginal hyperplasia)....... 10

Vaginal Prolapse.......... 10

Vaginal Neoplasia.......... 11

Vulvar Hypertrophy...... 11

Vulvar Hypoplasia / Infantile Vulva. 11

Mammary Neoplasia. 12

List of textbook references 13

 

 

OBJECTIVES

·         Know the signs and diagnostic findings for ovarian neoplasia

·         Know how to diagnose and treat pyometra.

·         Understand how the signs and diagnostic findings of metritis differ from pyometra.

·         Know how to diagnose and treat uterine prolapse.

·         Know the indications for and complications of ovariohysterectomy.

·         Know the indications for and complications of cesarean section.

·         Understand the surgical treatment options for persistent hymen.

·         Understand how the signs of vaginal edema, vaginal prolapse, and vaginal neoplasia differ.

·         Be familiar with the 3 main vaginal neoplasias.

·         Understand how the behavior of  mammary neoplasia differs between the dog and cat.

·         Be familiar with the various treatment options for mammary neoplasia.

Note: References to textbook illustrations have been provided and are marked by “ILL”, for those who are interested. Use of these references is optional and only provided for your convenience. A list of textbook references is provided at the end of these notes. If you are planning to work with small animals, you should consider owning at least one of these textbooks as a reference.

 

Surgical Conditions of the Ovaries

 

Congenital Anomalies

(uncommon)

Ovarian agenesis

ovaries absent unilaterally or bilaterally.

Ovarian hypoplasia

underdeveloped ovaries.

Supernumerary ovaries

True hermaphroditism

both ovarian and testicular tissue in the same individual.

Pseudohermaphroditism

the external genitalia is of the opposite sex as the gonads

Signs

may be no overt problems        

Surgical Treatment

Remove gonads.  May do cosmetic surgery on external genitalia.

 

Ovarian Cysts

Follicular cysts

most common type. single or multiple. may develop after incomplete removal at spay. 

Signs:

 persistent heat, mammary hyperplasia, or none. 

Diagnosis:

visualizing cyst at laparoscopy or laparotomy

Surgical Treatment:

 excision or rupture of cyst (or hormonal treatment) ovariohysterectomy (OHE)

 

Luteal cysts

release progesterone.  usually multiple

Signs: 

persistent anestrus, cystic endometrial hyperplasia, or pyometra. 

Surgical Treatment:

excise cyst or ovary (or hormonal treatment) OHE

 

Parovarian cysts

usually an incidental finding during routine spay.

 

Ovarian Neoplasia 

(uncommon)

more frequent in older, nulliparous bitches. 

Signs

- if increased production of  progesterone result is cystic endometrial hyperplasia or pyometra. 

- if increased production of estrogen result is persistent heat, aplastic anemia.

- enlarged abdomen due to large tumor or to ascites from peritoneal  metastasis.

- may have neurologic abnormalities if metastasis to CNS

Diagnosis

physical/neurologic exam (palpate mass in abdomen), vaginal cytology (cornification due to estrogen), serum progesterone (>2 ng/ml), CBC +/- bone marrow biopsy (anemia), abdominal and thoracic radiographs (primary tumor and/or metastasis), abdominal ultrasound, biopsy

Surgical Treatment

OHE.  if young, breeding dog with large calcified tumor (suspect teratoma), you may just excise the affected ovary.

Prognosis

good if benign and no aplastic anemia.  poor if metastasis or bone marrow suppression.

Adenoma/Cystadenoma  - may cause increased progesterone

Adenocarcinoma/Cystadenocarcinoma - most common ovarian tumor in bitches.  may have metastasis to abdominal organs and lungs causing ascites and hydrothorax

Granulosa cell tumor - increased estrogen or progesterone. most common ovarian tumor in queens.  may metastasize to abdominal organs or CNS. tends to be benign in bitch and malignant in queen.

Dysgerminoma - rarely cause signs. may metastasize to adjacent organs.   

Teratoma (Dermoid cyst) - may be asymptomatic or present for suspected pregnancy.  may be calcified.

Teratocarcinoma - often calcified. metastasizes regionally to bone so may be lame.

 

Surgical Conditions of the Uterus

 

Pyometra

Pyometra is inflammation of the uterus.  Etiopathogenesis is not clear, but progesterone plays a key role by increasing uterine secretions, decreasing contractions, and closing the cervix.  (Repeated estrous cycles can lead to cystic endometrial hyperplasia (CEH). However, pyometra can occur without CEH.)The uterus becomes more susceptible to infection - E. coli the most common, but other aerobes and anaerobes can also be isolated.

Signs

anorexia, PU/PD, depression, +/- vaginal discharge, vomiting, diarrhea, shock.

Diagnosis 

Signalment and history - usually occurs in bitches >6 yrs old, and usually within  8 weeks of estrus.                     

Physical exam - temperature may be normal. purulent or sanguineous vaginal discharge if cervix is open (open pyometra), no discharge if cervix is closed (closed pyometra).  +/- palpate enlarged uterus.

Lab data – may be normal, but usually have leukocytosis +/- left shift and hyperglobulinemia which indicate inflammation.  may have hypoalbuminemia due to decreased production, decreased intake, or loss in utero.  may have nonregenerative anemia due to loss of RBC's into lumen and toxic depression of production. may have prerenal azotemia.  may have low urine specific gravity - (how pyometra affects the kidneys is not clear.  one theory is that E. coli endotoxin or other toxins affect the ability of the renal tubules to reabsorb water. Antigen-antibody complex glomerulopathy? Direct effect of endotoxins?).  may  have urinary tract infection.  SAP can be elevated. can have metabolic acidosis.

Diagnostic imaging -  may see tubular soft tissue density on survey abdominal films.  radiographs may be nondiagnostic, but can usually identify fluid-filled tubular structure on abdominal ultrasound.

[ILL. Hedlund (2002) Fig 28-15 radiograph]

Surgical Treatment

broad spectrum antibiotics & fluid therapy

Ovariohysterectomy - Same as a routine OHE but the uterus is more friable (and may be filled with pus), so pack it off with laparotomy sponges to prevent contamination.  Culture the uterus!  Don't leave any uterine body in the dog.  Lavage the uterine stump with sterile saline and consider oversewing the end of the stump if mucosa is protruding - this can be done with interrupted Lembert sutures or a Parker-Kerr oversew. Disadvantages of oversewing are the potential for uterine stump granuloma or abscess.

Post op care:  Continue antibiotics for 7-10 days based on culture and sensitivity results.

Prognosis 

usually good.  If death occurs, it is usually due to septicemia.    

Medical Treatment

Not recommended.  Can be attempted if cervix is open and dog is a valuable breeding bitch.  Use antibiotics and PGF2a (not approved for use in dogs) to contract the myometrium, relax the cervix, and lyse the CL. (antibiotics can resolve bacterial infection, but medication does not alter any underlying CEH.)  Potential side effects include restlessness, salivation, vomiting, defecation, forcing pus through the oviducts into the peritoneal cavity, and uterine rupture.  Recurrence of pyometra is likely so she should be bred at the next estrus.

 

Hydrometra/Mucometra

accumulation of sterile fluid in the uterus - uncommon and usually an incidental finding.

 

Subinvolution of Placental Sites

 Placental sites do not degenerate and serosanguineous drainage is noted 7-12 weeks post partum.  It usually occurs in dogs <2 1/2 yrs old, with first or second litter.

Signs 

anemia due to hemorrhage, palpate enlarged uterine horns. R/O metritis, vaginitis, neoplasia.

Treatment 

OHE to stop blood loss. Spontaneous recovery is common.  Medical management may be tried using ergonovine, but success varies.

 

Metritis

 Similar to pyometra but metritis usually occurs postpartum and is associated with dystocia, obstetrical manipulation, or retained fetus or placenta.

Signs

anorexia, depression, vomiting, vaginal discharge, fever, mastitis.  (Differs from pyometra in that there is no PU/PD.)

Diagnosis

Signalment and history - usually occurs immediately postpartum.

Physical exam - fever.  malodorous, mucopurulent vaginal discharge

Lab data - usually have leukocytosis with degenerative left shift.  see degenerate PMNs and bacteria on cytology of the discharge.

Surgical Treatment

OHE is recommended if not a breeding animal or if she has severe systemic signs. Perform surgery and post op care as for pyometra.       

Medical Treatment

 consider if she is not too sick and is a breeding animal. Use systemic antibiotics and drain the uterus daily.  A soft rubber catheter can be passed if the cervix is dilated.  If a catheter cannot be passed, the uterus can be drained by laparotomy and hysterotomy.  You can also use ergonovine maleate or PGF2α as for pyometra.

 

Uterine Torsion

Usually occurs in a gravid uterus, etiology unknown.

Signs 

acute abdominal pain, vomiting, severe depression and collapse, shock.

Diagnosis 

supposedly can feel rotation on vaginal exam, but more likely to be diagnosed on exploratory.

Treatment 

OHE +/- cesarean section.  Do not derotate the uterus.

Prognosis

High mortality, especially if in DIC or peritonitis due to rupture.

 

Uterine Prolapse 

rare

Usually occurs at labor or within 48 hrs.   

Signs 

one or two tubular masses protruding from vulva. May be in shock if intra-abdominal bleeding.

Treatment 

- If uterus looks healthy, flush with warm saline and lubricate with a water soluble jelly.  Gently manipulate uterus to manually reduce. Recurrence is rare. 

- If manual reduction fails or the uterus is necrotic, amputate the uterus.  A smooth, cylindrical object is placed in the uterine lumen and 4 stay sutures are placed at equidistant points around the prolapsed uterus.  Incise through all layers to the inserted object, one quadrant at a time.  Immediately after incising one quadrant, anastomose the inner and outer layers of the prolapsed uterus with simple interrupted absorbable suture before incising the next quadrant.

- If uterus is replaced but uterine tissue is damaged or there is internal bleeding, may need OHE.

 

Uterine Rupture

May occur secondary to pregnancy or pyometra.  Can cause peritonitis.  If the tear is sutured, it may recur or fibrose, so do OHE or unilateral OHE.

 

Uterine Neoplasia

(rare)

Leiomyoma is the most common canine uterine neoplasia.  Adenocarcinoma is the most common feline uterine tumor. It may metastasis regionally, or to lungs, brain, or eyes.

Signs 

depends on tumor type, size and pattern of metastasis.  Illness is usually related to metastatic disease.

Diagnosis 

usually at OHE or necropsy.  May find in patient suspected of having pyometra.

Treatment

OHE after checking for metastasis.  Can try chemotherapy  for metastatic dz.

Prognosis

good for benign tumors.  poor for malignant tumors.

 

Common Surgeries of the Uterus

 

Ovariohysterectomy (OHE or OVH)

Indications

·         elective sterilization. This is recommended before 1st estrus to reduce risk of mammary neoplasia. May be done as early as 7 weeks in spay-neuter programs designed to reduce pet overpopulation problems. Main points to remember for early spay are to avoid hypothermia and hypoglycemia.

·         ovarian dz (cysts or neoplasia)

·         uterine disease (pyometra, subinvolution, metritis, torsion, rupture, neoplasia)

·         diseases related to hormone production (prevent mammary tumors, prevent vaginal edema, vaginal prolapse, help control unregulated diabetics)

 

Preoperative evaluation

·         physical exam

·         extent of diagnostic evaluation is related to animal's age and reason for surgery

 

 

 

Complications

Hemorrhage

during surgery or post operative (bleed into abdomen or vagina). More potential problems if OHE performed during estrus.

Recurrent estrus

due to incomplete ovary removal – e.g. if ligature placement is incorrect. If ovarian tissue is accidentally dropped into the abdomen it can revascularize or reimplant and be functional. Can diagnose by identifying cornified vaginal epithelial cells and/or increased serum progesterone (>2 ng/ml). Explore while there are signs of estrus when the tissue is enlarged and easier to find.

Uterine stump infection

especially if progesterone is present from ovary or exogenous source

Uterine or ovarian stump granuloma with or without fistulous tracts

 may occur secondary to braided nonabsorbable suture (Vetafil, silk)

Ligation of ureter 

will develop unilateral hydronephrosis.  If you ligate both ureters, the dog will go into anuric renal failure.  The ureters are usually damaged so they must be transected and reimplanted into the bladder. 

Urinary incontinence

estrogen responsive incontinence may occur and can be treated with diethlystilbesterol or phenylpropanolamine. No difference in incidence of this between animals spayed in an early spay-neuter program as compared to those spayed later.

Eunuchoid syndrome

decreased aggression and stamina.? Not proven

Weight gain

not a problem if diet and exercise are regulated.

Infantile vulva

Can occur  for animals who have surgery at 7 weeks of age, but generally has no clinical significance. (Males castrated young will also have smaller penis than those castrated later.)

 

Cesarean Section

Indications

·         complete primary uterine inertia (dachshunds and Scotties)

·         incomplete primary uterine inertia refractory to medical therapy

·         secondary uterine inertia (St. Bernards)

·         relative or absolute fetal oversize (brachycephalic fetus tend to have large head/shoulders)

·         anatomic abnormalities of pelvic canal (old pelvic fractures)

·         uncorrectable fetal malpresentation (transverse presentation)

·         fetal death with putrefaction (greyhounds)

·         toxemia (fetal death, uterine torsion, uterine rupture)

 

Preoperative care

warm IV fluids - correct any deficits prior to anesthesia, if possible (hypoglycemia, hypocalcemia)

antibiotics - if uterine infection, dead fetus, or manual manipulation

steroids - if septic shock

clip and scrub surgical site prior to anesthesia  - if possible without exciting bitch. 

surgery table should be warm and level  (doesn't need to be tilted)

final scrub under anesthesia

Anesthetic protocols

want optimum analgesia and immobilization of bitch with minimal compromise of fetuses.

Check your anesthesia notes for details on this. From a surgical standpoint, you want to be very efficient – so plan ahead and keep moving!

 

Surgical technique

approach: 

ventral midline abdominal.  (can also use flank approach to avoid mammary glands, but is more vascular, less familiar, and less exposure.)  pack off uterus with laparotomy sponges.

 

hysterotomy: 

longitudinal incision through avascular region of uterine body.  Gently advance fetus to incision, open amniotic sac, pull out puppy, clamp umbilical cord, place puppy on sterile towel and hand to nonsterile assistant.  Use gentle traction to remove placenta.  If it's firmly adhered, leave it.  Check to be sure uterus is empty of fetuses and placentas.  Can give oxytocin to stimulate uterine contractions and to help control bleeding.  close uterus with 1 or 2 layers, using continuous inverting suture pattern (Cushings or Lembert) with absorbable suture.

[ILL. Hedlund (2002) Fig 28-7 and 28-8 photos]

[ILL. Gilson (2003) Fig 101-1, 101-2, 101-3 drawings]

[ILL. Probst (1998) Fig 30-9 thru 30-13 drawings]

 

en bloc ovariohysterectomy:

This is an alternative to hysterotomy if the animal is to be spayed as well. Isolate the ovarian pedicles. break down the broad ligament between the ovary and cervix on both sides of the uterus. manipulate any fetuses from the cervix and vagina into the uterine body. Double clamp both ovarian pedicles and the uterus just cranial to the cervix. cut between the clamps and pass the ovaries and uterus to a team of nonsterile assistants, who can immediately open the uterus and resuscitate the neonates. double ligate the pedicles. The advantages of this procedure are that there is less chance for contamination by the uterine fluids, and it shortens the anesthesia time. A potential disadvantage is that you need enough assistants to resuscitate the entire litter at once.

[ILL. Mullen (1998) Fig 30-14 thru 30-17 drawings]

 

closure: 

obtain sample for culture and sensitivity followed by abdominal lavage if any spillage from uterus.  routine abdominal closure.

 

neonatal resuscitation:  

clean membranes and fluid from oral cavity and nostrils by swab or suction. can swing body and head in downward arc to clear fluid from airway. rub neonate with towel to stimulate respiration and to  dry. check for heartbeat and breathing (can give atropine or doxapram sublingual or by umbilical vein). give few drops of 50% glucose if not responding well. can give naloxone if bitch had narcotics. ligate umbilical cord if it bleeds when clamp is removed. keep warm. check for congenital defects.          

 

 

 

post operative care: 

clean incision. observe for hypothermia, depression, shock, excess vaginal bleeding. put puppies with bitch as soon as she is awake and watch for behavioral problems. puppies need colostrum and nursing stimulates oxytocin to promote uterine contraction. send home ASAP.

 

complications: 

hypovolemia/hypotension - due to blood loss, shock, anesthesia. treat with fluids and transfusions as needed.

uterine hemorrhage - check for coagulopathies. control with oxytocin or ergonovine maleate. transfuse if necessary.  may need OHE.

peritonitis - due to break in technique or sepsis
metritis

uterine scarring and adhesions - by third C sect may have decreased litter size and difficult to exteriorize the uterus. if the horn was incised, it may scar and prevent further placentation or cause abnormal fetal development.

agalactia - usually milk within 24 hrs.  oxytocin will stimulate milk let-down but not milk production.

prolapsed uterus

mastitis - enlarged, hot, painful mammary gland, fever, anorexia. Tx warm soaks.

retained placenta - will usually come out on its own. if not, may lead to septic metritis.

eclampsia - see trembling, weakness, convulsions, fever 2-4 wks post partum. usually small breeds with large litters. Tx Ca gluconate and vitamin D

subinvolution of placental sites - serosanguineous discharge. treat as for hemorrhage.

 

Surgical Conditions of the Vagina, Vestibule, and Vulva

 

Congenital Abnormalities

 

Segmental Vaginal Aplasia or Hypoplasia

segmental vaginal aplasia - complete occlusion and retention of uterine fluids

vaginal hypoplasia - partial occlusion

Signs

asymptomatic, vaginitis, inability to tie

Diagnosis

digital palpation, vaginoscopy, vaginography

Treatment options

- breeding bitch- can resect caudal and midvaginal strictures. incise longitudinally and suture transversely.

- nonbreeding symptomatic - OHE or vaginectomy

- nonbreeding asymptomatic - no Tx

 

Persistent Hymen

vertical septum or annular stricture at vestibulovaginal junction

Signs

difficulty breeding, chronic vaginitis, urine pooling, mucometra

Diagnosis

palpation, vaginogram, vaginoscopy

 

Treatment

- episiotomy - incise from dorsal vulvar commissure toward anus along median raphe. incise fascia and vulvar muscles, then mucosa. place urinary catheter.  resect septum.  close episiotomy in 3 layers.

- abdominal approach is needed if septum is > 2 cm cranial.

- vaginectomy is indicated if the stricture is cranial, if urine pools after the septum has been removed, or if surgical relief of the stricture was unsuccessful.

Prognosis

guarded if surgery site strictures post operatively

[ILL. Hedlund (2002) Fig 28-9 drawing of episiotomy]

[ILL. Manfra Marretta (1998) Fig 31-8 thru 31-11drawing of episiotomy]

[ILL. Wykes (2003) Fig 99-2 photo of persistent hymen]

 

Rectovaginal/Rectovestibular Fistula

often associated with imperforate anus. if large fistula - do okay until start on solid food, then may develop megacolon.    

Signs

feces from vulva or urine from anus. vaginitis, cystitis, frequent urination

Diagnosis

barium enema or barium in vagina

Treatment

ligate or oversew fistula. reconstruct wall.

Complications

incontinence. especially if had imperforate anus.

[ILL. Wykes (2003) Fig 99-5 drawing]

 

Acquired Abnormalities

Vaginal Edema (vaginal hyperplasia)

occurs during follicular phase, usually during first estrus and may recur. may also recur at parturition and cause problems.  brachycephalics are predisposed.

Signs

mass cranial to urethral papilla, may protrude through vulvar labia. can desiccate or become traumatized. urethra is easily catheterized.

Treatment options

-  if mild, keep moist with soluble jelly until it reduces during diestrus. megestrol acetate (progesterone) to prevent, but also prevents ovulation.

- GnRH - can cause cysts.

- surgical resection - episiotomy and resect at base, close vaginal mucosa. may recur at next heat

- OHE - Tx of choice if not a breeding bitch

[ILL. Wykes (2003) Fig 99-6 drawing]

[ILL. Pettit (1998) Fig 31-1 drawing]

 

Vaginal Prolapse

(uncommon)

may be hereditary. brachycephalics are predisposed. may precede uterine prolapse. occurs during periods of increased estrogen. rare during pregnancy

Diagnosis

donut shaped eversion of vagina, may see urethral papilla

Treatment options

-  if mild, will spontaneously regress during diestrus - keep moist

- replace. may suture uterus or broad ligament to abdominal wall, or suture labia

- resect devitalized tissue (first do episiotomy and place urinary catheter)

- OHE is curative - will cause regression if not a chronic prolapse.

[ILL. Wykes (2003) Fig 99-7 drawing]

[ILL. Pettit (1998) Fig 31-2 drawing]

 

Vaginal Neoplasia

Most common location for female (intact or spayed) reproductive tract tumors.  Predisposition for boxer, poodle, and German shepherd.  Most are leiomyoma or transmissible venereal tumor (TVT).

Signs

bulging of perineum, vaginal prolapse, tenesmus, dysuria, urinary incontinence, difficulty copulating, sanguinous or purulent discharge

Diagnosis

vaginoscopy, digital vaginal exam, rectal palpation in small dogs, cytology.  Abdominal and thoracic radiographs.

Treatment

Surgical excision - usually easy to remove with episiotomy.

Prognosis

good for completely removed leiomyoma or for TVT     

 

Leiomyoma - often multiparous bitches.  Tumor is slow growing and associated with tenesmus and dysuria. usually completely encapsulated and can be excised. Sessile or pedunculated. Often reported with chronic estrogen (ovarian tumor or follicular cyst). do not usually metastasize.

Leiomyosarcoma - metastasize to lymph nodes, spleen, lungs, or cervical spinal cord and may recur without metastasis

Transmissible Venereal Tumor (TVT) - transmission, growth, and metastasis depends on immune status of recipient.  May regress or grow slowly in normal animal, may grow quickly and metastasize in immunosuppressed animal.  Treatment for TVT depends on tumor location, presence of metastasis, and availability of treatment modalities.  Sx excision of TVT is associated with high rate of recurrence. Chemotherapy using vincristine has a high cure rate and is useful for metastatic disease.  Orthovoltage radiation therapy works for local tumors.

 

Vulvar Hypertrophy

may persist with prolonged estrogen due to cystic ovaries, granulosa cell tumor

Treatment

OHE

 

Vulvar Hypoplasia / Infantile Vulva

(recessed vulva, vulvar inversion)

may be more common in dogs that are spayed at an early age, but not proven. Has also been described in intact females. Obesity may also be a factor.

Signs

vulva is hidden into folds of adjacent skin, perivulvar dermatitis. Has also been associated with chronic urinary tract infections, urinary incontinence, and vaginitis.

 

Treatment

weight loss is indicated if the animal is obese.

local cleaning of the skin.

episioplasty - crescent shaped bilateral piece of skin removed dorsal and lateral to vulva. remove underlying fat. close subcutaneous tissue and skin.

[ILL. Hedlund (2002) Fig 28-10 drawing of episioplasty]

[ILL. Manfra Marretta (1998) Fig 31-4 thru 31-7drawing of episioplasty]

 

Mammary Neoplasia

 

Incidence

dogs:  most common neoplasia. most commonly in caudal 2 glands.  intact females have 3-7 x increased risk compared to spayed.  spaying has no protective effect after 2.5 yrs or 4 estrus cycles.

[ILL. Hedlund (2002) Fig 28-13 photo]

 

cats: 3rd most common neoplasia. all glands at equal risk.  intact female has 7x increased risk as compared to spayed.   Siamese cats are predisposed.

 

Tumor type and Metastasis

dogs:   about 50% benign. (fibroadenoma) most malignant are adenocarcinoma and have mets  to lungs or lymph nodes.

cats: 90% are malignant (adenocarcinoma, also sarcoma and inflammatory carcinoma) and most have mets - lungs and regional nodes.

Influence of Reproductive Hormones on Occurrence

estrogen and progesterone have role in etiology. bind protein receptors in target tissue. patients with receptor rich tumors have greater survival than patients with receptor poor tumors.

 

Diagnosis

history, signalment, physical exam

cytology

abdominal and thoracic radiographs and abdominal ultrasound

histopathology

 

Treatment Options

Surgical excision

            lumpectomy - remove tumor

            simple mastectomy (mammectomy) - remove affected gland

            en bloc resection - remove affected gland, regional LN, and all glands in between

            unilateral mastectomy - remove all glands on affected side and associated LN

            bilateral mastectomy

[ILL. Hedlund (2002) Fig 28-14 drawing]

 

Use an elliptical incision, as for any mass removal. Be careful not to get too wide or may have trouble closing. Depth of excision should be to pectoral muscles/abdominal wall fascia. Use good hemostatis and use walking sutures to eliminate dead space and tension. Bilateral mastectomies may need to be staged, removing the second mammary chain 2-4 weeks after the first.

Type of surgery does not affect survival time or cancer free time, so lumpectomy or simple mastectomy of affected glands may be Tx of choice. The most important thing is to get clean margins. 44% of dogs have receptor rich malignant tumors and concurrent OHE of these bitches will increase survival time. (OHE is cheaper than steroid receptor assay.)

cats- unilateral mastectomy have better disease free interval than simple mastectomy but  no difference in survival. OHE is not indicated because cat mammary tumors are receptor poor.

 
Other therapy:
-Chemotherapy

-Radiation therapy

-Immuinotherapy

 

Prognosis

dogs: depends on tumor size, type, mode of growth and clinical stage. < 5 cm diameter, no invasion or mets - survival same as for benign.  75% of dogs with simple mastectomy  or enbloc did not survive >2 yrs

cats:  average survival 1 year

either species: tumors with lymphatic infiltration, metastasis, body wall invasion, rapid growth, or recurrence have a  poor prognosis

 

List of textbook references

 

Gilson SD. Cesarean section In: D. Slatter, ed. Textbook of Small Animal Surgery. 3rd ed. Philadelphia: Saunders, 2003;1517-1520.

 

Hedlund CS. Surgery of the reproductive and genital systems In: T. W. Fossum, ed. Small Animal Surgery. 2nd ed. St Louis: Mosby, 2002;610-674.

 

Manfra Marretta S. Episioplasty In: M. J. Bojrab, ed. Current Techniques in Small Animal Surgery. 4 ed. Baltimore: Williams and Wilkins, 1998;506-508.

 

Manfra Marretta S. Episiotomy In: M. J. Bojrab, ed. Current Techniques in Small Animal Surgery. 4 ed. Baltimore: Williams and Wilkins, 1998;508-510.

 

Mullen HS. Cesarean section by ovariohysterectomy In: M. J. Bojrab, ed. Current Techniques in Veterinary Surgery. 4 ed. Baltimore: Williams and Wilkins, 1998;500-502.

 

Pettit GD. Surgical treatment of vaginal and vulvar masses In: M. J. Bojrab, ed. Current Techniques in Small Animal Surgery. 4 ed. Baltimore: Williams and Wilkins, 1998;503-506.

 

Probst CW. Cesarean section In: M. J. Bojrab, ed. Current Techniques in Small Animal Surgery. 4 ed. Baltimore: Williams and Wilkins, 1998;496-500.

 

Wykes PM, Olson PN. Vagina, vestibule, and vulva In: D. Slatter, ed. Textbook of Small Animal Surgery. 3rd ed. Philadelphia: Saunders, 2003;1502-1510.


Theriogenology VMED 5361

SURGERY OF THE MALE REPRODUCTIVE SYSTEM

Fall 2002

Dr. J. Davidson

 

OUTLINE

 

SURGICAL CONDITIONS OF THE PROSTATE. 2

General Evaluation of Prostatic Disorders. 2

Benign Prostatic Hyperplasia and Cystic Hyperplasia. 3

Suppurative Prostatitis and Prostatic Abscessation. 3

Prostatic Cysts and Paraprostatic Cysts. 4

Prostatic Neoplasia. 5

TECHNIQUES FOR SURGERY OF THE PROSTATE. 6

General Considerations for Prostatic Surgery. 6

Prostatic Biopsy. 6

Prostatic Drainage. 6

Marsupialization. 6

Prostatic Omentalization. 7

Partial Prostatectomy. 7

Complete Prostatectomy. 7

SURGICAL CONDITIONS OF THE TESTES. 7

Testicular Hypoplasia. 7

Cryptorchidism.. 7

Orchitis. 8