Research:
Dr
Kleinow's research interests center on mechanistic and applied aspects of
aquatic animal toxicology, physiology and pharmacology. Focus areas include
1) biotransformation and transporter functions as modulators of xenobiotic
bioavailability and excretion; 2) elaboration of basic mechanisms involved
in the disposition of carcinogens, drugs and other xenobiotics in aquatic
species; 3) the food chain transfer and consumption of xenobiotics within
and from the aquatic food chain and 4) dispositional aspects of developmental
toxicity.
Recent
Publications:
Doi,
A.M, Z. Lou, E. Holmes, C.-L.J. Li, C.S. Venugopal, M.O. James and K.M.
Kleinow. 2000. Effect of micelle
fatty acid composition and 3,4,3 ,4 -tetrachlorobiphenyl (TCB) exposure
on intestinal [14C]-TCB bioavailability and biotransformation
in channel catfish in situ preparations.
Toxicological Sciences. 55:
85-96.
Kleinow,
K.M., A.M. Doi, and A.A. Smith. 2000.
Distribution and inducibility of P-glycoprotein in the catfish: Immunohistochemical
detection using the mammalian C-219 monoclonal.
Marine Environmental Research.
50: 313-317.
James,
M.O., Z. Tong, L. Rowland-Faux, C.S. Venugopal and K.M. Kleinow.
2001. Intestinal bioavailability and biotransformation of 3-hydroxy-benzo(a)pyrene
in an isolated perfused preparation from channel catfish, Ictalurus punctatus.
Drug Metabolism and Disposition 29:721-728.
Doi,
A.M., E. Holmes and K.M. Kleinow.
2001. P-glycoprotein
in the catfish intestine: Inducibility by xenobiotics and functional properties.
Aquatic Toxicology. 55(3-4): 157-170.
Kleinow,
K.M. and M.O James. 2001. Response
of the teleost gastrointestinal system to xenobiotics. In Target Organ Toxicity in Marine and Freshwater
Teleosts, Volume 1, Chapter 5.
D. Schlenk and W.H. Benson Eds.
Taylor and Francis, London
pp. 269-362. |
