Research
The
long-term goal of my research is threefold: 1) To elucidate the molecular
and cellular mechanisms underlying regulation of the cAMP signaling pathway
in the central nervous system, 2) To determine the role that the cAMP signaling
pathway plays in the physiological and behavioral responses of an animal,
and 3) To elucidate the pathways that transduce change in cAMP signaling
into the physiological and behavioral manifestations. In particular, I am
interested in the effects of ethanol on the cAMP signaling system and the
role that this signaling pathway has in an animal’s responses to ethanol.
My research program will be interdisciplinary covering molecular biology
and pharmacology of the cAMP signaling system, generation of transgenic
and gene targeted animals, electrophysiology of neuronal activity, behavioral
analysis of model animals, and gene expression study.
Recent
Publications:
Kou, J. and Yoshimura, M. (2007) Isoform specific enhancement of adenylyl cyclase activity by n-alkanols. Alcohol. Clin. Exp. Res .31, 1467-1472.
Yoshimura, M., Pearson, S., Kadota, Y. and Gonzalez, C.E. (2006) Identification of ethanol responsive domains of adenylyl cyclase. Alcohol. Clin. Exp. Res . 30, 1824-1832.
Hines, L.M., Hoffman, P.L., Bhave, S., Saba, L., Kaiser, A., Snell, L., Goncharov, I., LeGault, L., Dongier, M., Grant, B., Pronko, S., Martinez, L., Yoshimura, M. and Tabakoff, T.; WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence Investigators. (2006) A sex-specific role of type VII adenylyl cyclase in depression. J. Neurosci. 26, 12609-12619.
Yoshimura,
M and Pearson, S. (2004) Ethanol-Responsive Domains in Adenylyl Cyclase.
Proceedings of the 12th International Conference on Second Messengers and
Phosphoproteins, 235-239.
Nelson, E.J. Hellevuo, K., Yoshimura, M. And Tabakoff, B. (2003) Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase: involvement of PKC delta. J. Biol. Chem. 278, 4552-4560. |
