Research:

My major research emphasis focuses on the molecular regulation of bone resorption and bone formation, especially bone remodeling for tooth eruption.  Bone resorption is required to form a pathway before a tooth can erupt.  Concurrently, bone formation at the base of the tooth crypt serves as a motive force to push the tooth out of the crypt. The study of bone remodeling is also significant in understanding many bone diseases, such as is seen in osteoporosis and periodontitis.  In addition, I am interested in purifying and culturing stem cells from dental tissues and differentiating them into various specialized cell types for potential uses in regenerative medicine.

Recent Publications:

G.E. Wise, S. Yao and W.G. Henk (2007). Bone formation as the motive force of tooth eruption in the rat molar. Clinical Anatomy (in press).

S. Yao, F. Pan and G.E. Wise (2007). Chronological gene expression of parathyroid hormone-related protein (PTHrP) in the stellate reticulum of the rat—implication for tooth eruption. Archives of Oral Biology 52:228-232.

G.E. Wise and S. Yao (2006). Regional differences of expression of BMP-2 and RANKL in the rat dental follicle. European Journal of Oral Sciences 114:512-516.

D. Liu, S. Yao and GE. Wise (2006).  Effect of IL-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle. European Journal of Oral Sciences. 114:42-49.

S. Yao, D. Liu, F. Pan and G.E. Wise (2006).  Effect of vascular endothelial growth factor on RANK gene expression in osteoclast precursors and on osteoclastogenesis. Archives of Oral Biology 51:596-602.