Inder Sehgal

Associate Professor
D.V.M. Ohio State University
Ph.D., Mayo Clinic and Foundation
Fellowship (urology research), Baylor College of
Medicine

Phone: (225) 578-9764
Fax: (225) 578-9895

Office: Rm 2419 Vet. Med.

E-Mail: isehgal@vetmed.lsu.edu

Research:

Research Summary-Most deaths from solid malignancies result from tumor dissemination and it is the broad objective of my laboratory to investigate mechanisms for prostate cancer metastasis.

The basement membrane is a structural matrix that contains cells within their microenvironment. Prostate tumor cells that become metastatic are able to break through this barrier, in part, by utilizing matrix degrading enzyme systems such as matrix metalloproteinases (MMPs) and the urokinase-plasmin (uPA) system. My research program works on identifying and exploring pathways which regulate these protease systems so that they can be selectively targeted through inhibition or prevention strategies.

Recent Publications:

Inder Sehgal, Martha Sibrian-Vazquez, and M. Graça H. Vicente.  Photo-induced Cytotoxicity and Biodistribution of Prostate Cancer Cell-targeted Porphyrins  J Med Chem. 2008, 51:6014-20.

Mohammad Hasanuzzaman, Robert Kutner, Siamak Agha-Mohammadi, Jakob Reiser, and Inder Sehgal. A Doxycycline-inducible Urokinase Receptor (uPAR) Upregulates uPAR Activities
Including Resistance to Anoikis in Human Prostate Cancer Cell Lines.  Molecular Cancer, 6:34, 2007.

Anna H. Israyelyan, Jeffrey M. Melancon, Larry G. Lomax, Inder Sehgal , Carola Leuschner, Michael T. Kearney, Vladimir N. Chouljenko, and Konstantin G. Kousoulas.  Effective Treatment of Human Breast Tumors in a Mouse Xenograft Model with a Herpes Simplex Virus Type-1 Specifying a Single Deletion of the γ134.5 gene and the gBsyn3 Syncytial Mutation.  Human Gene Therapy, 18:457-73, 2007.

Anuradha Guggilam, Masudul Haque, Kenneth Kerut, Elizabeth McIIwain, Pamela Lucchesi, Inder Sehgal, Joseph Francis.  TNF-alpha Blockade Decreases Oxidative Stress in the Paraventricular Nucleus and Attenuates Sympathoexcitation in Heart Failure Rats.   American Journal of Physiology---Heart and Circulatory Physiology, 293:H599-609, 2007. 

Inder Sehgal, Timothy P. Foster, Joseph Francis. Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis. Cancer Cell International, 6:23, 2006.