Inder Sehgal

Associate Professor
D.V.M. Ohio State University
Ph.D., Mayo Clinic and Foundation
Fellowship (urology research), Baylor College of
Medicine

Phone: (225) 578-9764
Fax: (225) 578-9895

Office: Rm 2419 Vet. Med.

E-Mail: isehgal@vetmed.lsu.edu

Research:

Research Summary-Most deaths from solid malignancies result from tumor dissemination and it is the broad objective of my laboratory to investigate mechanisms for prostate cancer metastasis.

The basement membrane is a structural matrix that contains cells within their microenvironment. Prostate tumor cells that become metastatic are able to break through this barrier, in part, by utilizing matrix degrading enzyme systems such as matrix metalloproteinases (MMPs) and the urokinase-plasmin (uPA) system. My research program works on identifying and exploring pathways which regulate these protease systems so that they can be selectively targeted through inhibition or prevention strategies.

Recent Publications:

Forbes, K., Gillette, K.M., Sehgal, I. The antitumor anitoxidant lycopene induces expression of the urokinase receptor in bone metastasis-derived prostate cancer cells. In Press, Experimental Biology and Medicine, September 2003

Forbes, K., Gillette, K.M., Kelly, L., Sehgal, I Urokinase Plasminogen Activator Receptor (uPAR) is increased in re-metastasized prostate cancer cells. In Press, World Journal of Urology, 2003

Sehgal, I., Forbes, K., and Webb, M.A. Reduced expression of MMPs, plasminogen activators and TIMPS in prostate cancer cells during repeated metastatic selection. Anticancer Research, 23: 39-42, 2003.

Naughton, C.A., Duppong, L, Forbes, K., and Sehgal, I. Erythropoietin within EPOGEN® syringes stored refrigerated for 3 and 6 weeks maintains protein integrity, glycosylation, and biological activity. American Journal of Health-System Pharmacy, 60:464-468, 2003.

Greiff, A., Fischer, W.M., and Sehgal, I. Paracrine communication between malignant and non-malignant prostate epithelial cells in culture alters growth rate, matrix protease secretion and in vitro invasion. Clinical & Experimental Metastasis, 19:727-733, 2002.