Shisheng Li

Associate Professor
B. S. Henan Normal University, China
M.S. Nankai University, China
Ph.D., University of Wales Swansea, UK

Phone: (225) 578-9102
Fax: (225) 578-9895
Lab: (225) 578-9025

Office: Rm 2325 Vet. Med.

E-Mail: shli@vetmed.lsu.edu

Research:

DNA, the genetic material of most living organisms, is under constant assault by endogenous and exogenous agents. A plethora of genotoxic agents exist, from oxidizing chemicals produced naturally in the cell to different type of radiation present in our environment. The DNA damage caused by these agents may interfere with normal cell processes, and if left unattended, the DNA damage may kill the organism or give rise to heritable mutations. To contend with DNA damage, all living organisms use multiple, highly conserved DNA repair pathways. Genetic and biochemical approaches are being used to elucidate the mechanisms of different DNA repair pathways, especially nucleotide excision repair and base excision repair.

Recent Publications:

Chen, X., Ruggiero, C. and Li, S. (2007) Yeast Rpb9 plays an important role in ubiquitylation and degradation of Rpb1 in response to UV induced DNA damage. Molecular and Cellular Biology 27, 4617-4625.

Ding, B., Ruggiero, C., Chen, X. and Li, S. (2007). Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast. DNA Repair 6, 1661-1669.

Li, S., Ding, B., LeJeune, D., Ruggiero, C., Chen, X. and Smerdon, M.J. (2007). The roles of Rad16 and Rad26 in repairing repressed and actively transcribed genes in yeast. DNA Repair 6, 1596-1606.

Li, S., Ding, B., Chen, R., Ruggiero, C. and Chen, X. (2006) Evidence that transcription elongation function of Rpb9 is involved in transcription coupled DNA repair in Saccharomyces cerevisiae. Molecular and Cellular Biology 26, 9430-9441.

Li, S., Chen, X., Ruggiero, C., Ding, B. and Smerdon, M. (2006) Modulation of Rad26 and Rpb9 mediated DNA repair by different promoter elements. Journal of Biological Chemistry 281, 36643-36651.